Set in the heart of the city, the Thistle Piccadilly is close to many major business and tourism sites. Leicester Square, the National Gallery, Piccadilly Circus, Trafalgar Square, the Soho district, and the West End theater district are all within a mile of the grounds. The Thistle Piccadilly is located on Coventry Street, which is 17.6 miles from the London Heathrow Airport.

Each of the guest bedrooms in the Thistle Piccadilly will come furnished with satellite TV, a minibar, a personal safe, climate controls, a full-sized bathroom with tub, a beverage station, a hair dryer, wake up service, high-speed Internet access, and direct dial phone service.

When staying at the hotel guests will be able to rely on the many amenities which include 24-hour front desk service, a lounge with bar service, laundry and dry cleaning services, a currency exchange, a florist shop, meeting and conference rooms, an in-house restaurant, banqueting facilities, a business service center, a concierge desk, free daily breakfast service, free parking on the premises, and room service.